Radical allylation with a-branched allyl sulfones

Nicolas Charrier (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

(Chemical Equation Presented) Branching out with sulfones: The use of allyl isopropyl sulfones solves the problem of premature isomerization and allows the radical addition of xanthates to a-branched allyl sulfones (see scheme; DCE=1,2-dichloroethane, TMS=trimethylsilyl). Highly functionalized structures can thus be rapidly assembled under mild reaction conditions by using cheap and readily available substrates and reagents. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

Domaines: Chimie organique

Nicolas Charrier, Samir Z. Zard. Radical allylation with a-branched allyl sulfones. Angewandte Chemie International Edition, 2008, 47 (49), pp.9443-9446. ⟨10.1002/anie.200804298⟩. ⟨hal-00951276⟩