Short cuts toward forskolin synthesis: A pentacyclic approach

Massoumé Leclaire; Raymond Levet; Franck Ferreira; Paul-Henri Ducrot; Jean-Yves Lallemand; Louis Ricard

Short cuts toward forskolin synthesis: A pentacyclic approach

Massoumé Leclaire ^{1, *} Raymond Levet ¹ Franck Ferreira ¹ Paul-Henri Ducrot ² Jean-Yves Lallemand ³ Louis Ricard ³

* Corresponding author

1 DCSO - Laboratoire de synthèse organique

2 Unité de phytopharmacie et médiateurs chimiques

3 DCPH - Laboratoire Hétéroéléments et Coordination

Abstract : A practical synthetic route for the preparation of forskolin intermediate 20 is described. Previously reported lactone 3 was converted to 20 through intermediate 16. The main feature of this work lies in the formation and the cleavage of a tetracyclic intermediate for the stereochemical control in the formation of the tricyclic core of forskolin.

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Journal articles

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https://hal-polytechnique.archives-ouvertes.fr/hal-00954908
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Submitted on : Tuesday, March 11, 2014 - 1:10:39 PM
Last modification on : Wednesday, March 20, 2019 - 12:12:31 PM

Short cuts toward forskolin synthesis: A pentacyclic approach

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Short cuts toward forskolin synthesis: A pentacyclic approach

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