Short cuts toward forskolin synthesis: A pentacyclic approach

Abstract : A practical synthetic route for the preparation of forskolin intermediate 20 is described. Previously reported lactone 3 was converted to 20 through intermediate 16. The main feature of this work lies in the formation and the cleavage of a tetracyclic intermediate for the stereochemical control in the formation of the tricyclic core of forskolin.
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Massoumé Leclaire, Raymond Levet, Franck Ferreira, Paul-Henri Ducrot, Jean-Yves Lallemand, et al.. Short cuts toward forskolin synthesis: A pentacyclic approach. Chemical Communications, Royal Society of Chemistry, 2000, pp.1737-1738. ⟨10.1039/B004515M⟩. ⟨hal-00954908⟩

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